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Article

Molecular mechanisms involved in high glucose-induced valve calcification in a 3D valve model with human valvular cells.

Journal of cellular and molecular medicine - 1 Jun 2020

Vadana Mihaela, Cecoltan Sergiu, Ciortan Letitia, Macarie Razvan D, Tucureanu Monica M, Mihaila Andreea C, Droc Ionel, Butoi Elena, Manduteanu Ileana

Abstract excerpt

Calcific aortic valve disease (CAVD)-the most common valvular heart disease-is accelerated in diabetes and has no pharmacotherapy. Although it is known that early CAVD is associated with inflammation and osteogenesis, the molecular mechanisms involved in diabetes-associated CAVD still need to be uncovered. In this context, we have developed a 3D construct based on gelatin populated with human valvular endothelial...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32307869
DOI: 10.1111/jcmm.15277
PMCID: PMC7294117

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