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Article

Scaffold-free high throughput generation of quiescent valvular microtissues.

Journal of molecular and cellular cardiology - 1 May 2017

Roosens Annelies, Puype Inès, Cornelissen Ria

Abstract excerpt

AIMS: The major challenge of working with valvular interstitial cells in vitro is the preservation or recovery of their native quiescent state. In this study, a biomimetic approach is used which aims to engineer small volume, high quality valve microtissues, having a potential in regenerative medicine and as a relevant 3D in vitro model to provide insights into valve (patho)biology. METHODS AND RESULTS: To form...

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Identifiers

PMID: 28322869
DOI: 10.1016/j.yjmcc.2017.03.004

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