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Article

Genetic determined low response to thienopyridines is associated with higher systemic inflammation in smokers.

Pharmacogenomics - 1 Jan 2015

Shahabi Payman, Cuisset Thomas, Stathopoulou Maria G, Morange Pierre Emmanuel, Grosdidier Charlotte, Herbeth Bernard, Siest Gérard, Alessi Marie-Christine, Visvikis-Siest Sophie

Abstract excerpt

AIM: To investigate whether the interactions of CYP2C19*2 and CYP2C19*17 with smoking are associated with the levels of P2Y12 receptor inhibition and CRP, in on-thienopyridine post-stenting patients. METHODS & RESULTS: At 1-month follow-up, the interactions of smoking and CYP2C19 polymorphisms on the vasodilator-stimulated phosphoprotein - platelet reactivity index (VASP PRI), and CRP were explored in three...

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Identifiers

PMID: 25916518
DOI: 10.2217/pgs.15.17

Genes

CRP
VASP

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