Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.

doi:10.1371/journal.pgen.1005853

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.

PLoS genetics - 1 Mar 2016

Binder Michele D, Fox Andrew D, Merlo Daniel, Johnson Laura J, Giuffrida Lauren, Calvert Sarah E, Akkermann Rainer, Ma Gerry Z M, Perera Ashwyn A, Gresle Melissa M, Laverick Louise, Foo Grace, Fabis-Pedrini Marzena J, Spelman Timothy, Jordan Margaret A, Baxter Alan G, Foote Simon, Butzkueven Helmut, Kilpatrick Trevor J, Field Judith

Abstract excerpt

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibility. However, the biologically relevant variants underlying disease risk have not been defined for the vast majority of these loci, limiting the power of these genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to c-Mer Tyrosine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Association Studies

Share to HLA-DRB1 Chains

Share to Monocytes

Share to Multiple Sclerosis

Share to Proto-Oncogene Proteins

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26990204
DOI: 10.1371/journal.pgen.1005853
PMCID: PMC4798184

Genes

MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.PMID 26990204Read ↗

Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.Semantic proximity Read ↗

The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.Semantic proximity Read ↗

Low frequency and rare coding variation contributes to multiple sclerosis riskSemantic proximity Read ↗

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.Semantic proximity Read ↗

Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655.Semantic proximity Read ↗

Risk HLA Variants Affect the T-Cell Repertoire in Multiple SclerosisSemantic proximity Read ↗

Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene.Semantic proximity Read ↗

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.Semantic proximity Read ↗

Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study.Semantic proximity Read ↗

MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients.Semantic proximity Read ↗

CTLA4 is associated with susceptibility to multiple sclerosis.Semantic proximity Read ↗

Contribution of common risk variants to multiple sclerosis in Orkney and Shetland.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.