Article

Low frequency and rare coding variation contributes to multiple sclerosis risk

2018-03-23

Abstract excerpt

Multiple sclerosis is a common, complex neurological disease, where almost 20% of risk heritability can be attributed to common genetic variants, including >230 identified by genome-wide association studies (Patsopoulos et al., 2017). Multiple strands of evidence suggest that the majority of the remaining heritability is also due to the additive effects of individual variants, rather than epistatic interactions be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f8cb38c-6631-53a6-a282-dd9df88ae0c2
DOI: 10.1101/286617

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low frequency and rare coding variation contributes to multiple sclerosis riskDOI 10.1101/286617Read

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis RiskSemantic proximity Read

Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved QuestionsSemantic proximity Read

The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years.Semantic proximity Read

Multiple sclerosis genetics.Semantic proximity Read

Multiple sclerosis genetics.Semantic proximity Read

Genome‐wide association studies of multiple sclerosisSemantic proximity Read

Multiple sclerosis genetics--is the glass half full, or half empty?Semantic proximity Read

Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs.Semantic proximity Read

Targeted resequencing reveals rare variants enrichment in multiple sclerosis susceptibility genes.Semantic proximity Read

The genetic architecture of multiple sclerosis in 2026: From susceptibility to disease progression.Semantic proximity Read

Multiple Sclerosis patients carry an increased burden of exceedingly rare genetic variants in the inflammasome regulatory genesSemantic proximity Read

C6orf10 Low-Frequency and Rare Variants in Italian Multiple Sclerosis PatientsSemantic proximity Read