Article
LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2016
Guffanti Guia, Gaudi Simona, Klengel Torsten, Fallon James H, Mangalam Harry, Madduri Ravi, Rodriguez Alex, DeCrescenzo Paula, Glovienka Emily, Sobell Janet, Klengel Claudia, Pato Michele, Ressler Kerry J, Pato Carlos, Macciardi Fabio
Abstract excerpt
Recent studies show that human-specific LINE1s (L1HS) play a key role in the development of the central nervous system (CNS) and its disorders, and that their transpositions within the human genome are more common than previously thought. Many polymorphic L1HS, that is, present or absent across individuals, are not annotated in the current release of the genome and are customarily termed "non-reference L1s." We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.