Article
eQuIPS: eQTL Analysis Using Informed Partitioning of SNPs - A Fully Bayesian Approach.
Genetic epidemiology - 1 May 2016
Boggis E M, Milo M, Walters K
Abstract excerpt
We develop a Bayesian multi-SNP Markov chain Monte Carlo approach that allows published functional significance scores to objectively inform single nucleotide polymorphism (SNP) prior effect sizes in expression quantitative trait locus (eQTL) studies. We developed the Normal Gamma prior to allow the inclusion of functional information. We partition SNPs into predefined functional groups and select prior...
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