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Mitochondrial DNA 4977-base pair common deletion in blood leukocytes and melanoma risk.

Pigment cell & melanoma research - 1 May 2016

Shen Jie, Wan Jie, Huff Chad, Fang Shenying, Lee Jeffrey E, Zhao Hua

Abstract excerpt

The 4977-base pair common deletion DmtDNA4977 is the most frequently observed mitochondrial DNA mutation in human tissues. Because mitochondrial DNA mutations are mainly caused by reactive oxygen species (ROS), and given that oxidative stress plays an important role in melanoma carcinogenesis, the investigation of DmtDNA4977 may be particularly relevant to the development of melanoma. In this study, we compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26988264
DOI: 10.1111/pcmr.12474
PMCID: PMC5520800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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