Article

P53 expression, Genome-wide transcriptome profiling and LGS test (a blood test to detect cancer): comparison of UVA exposed lymphocytes from malignant melanoma patients and healthy controls.

2023-03-06

Abstract excerpt

This study aimed to evaluate the expression of the P53 gene following exposure to varying doses of UVA radiation, using lymphocytes as surrogates. Lymphocytes from malignant melanoma (MM) patients (n = 20) with positive sentinel nodes were compared to healthy controls (HC)(volunteers) (n = 20). These samples were processed by Comet assay following the Lymphocyte Genome Sensitivity (LGS) test, quantitative real-tim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6743e2f-384b-5cb0-9461-93ca5a1da632
DOI: 10.21203/rs.3.rs-2540105/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P53 expression, Genome-wide transcriptome profiling and LGS test (a blood test to detect cancer): comparison of UVA exposed lymphocytes from malignant melanoma patients and healthy controls.DOI 10.21203/rs.3.rs-2540105/v1Read

Ultraviolet light and melanoma.Semantic proximity Read

Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair.Semantic proximity Read

Current Insights into the Role of UV Radiation-Induced Oxidative Stress in Melanoma PathogenesisSemantic proximity Read

Oxidative Stress and Genotoxicity in Melanoma Induction: Impact on Repair Rather Than Formation of DNA Damage?Semantic proximity Read

Sun Exposure and Melanoma, Certainties and Weaknesses of the Present KnowledgeSemantic proximity Read

RNA-Seq analysis revealed genes associated with UV-induced cell necrosis through MAPK/TNF-α pathways in human dermal fibroblast cells as an inducer of premature photoagingSemantic proximity Read

Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? A Comparison of UV Mutational Signatures in Malignant Melanoma and Mycosis Fungoides.Semantic proximity Read

Expression Profiling of UVB Response in Melanocytes Identifies a Set of p53-Target GenesSemantic proximity Read

DNA damage and repair in melanoma and non-melanoma skin cancer.Semantic proximity Read

Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? Comparison of UV Mutational Signatures Between Malignant Melanoma and Mycosis Fungoides.Semantic proximity Read

Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma.Semantic proximity Read

Different types of DNA damage play different roles in the etiology of sunlight-induced melanoma.Semantic proximity Read