Article

UVA irradiation promotes ROS-mediated formation of the common deletion in mitochondrial DNA

2025-07-11

Abstract excerpt

Ultraviolet (UV) radiation from the sun causes adverse skin changes such as premature aging. UVA radiation is the primary factor for photoaging due to its deep penetration into the dermis, and UV-induced mitochondrial DNA (mtDNA) alterations, including deletions, contribute to photoaging and cellular dysfunction. The most frequent mtDNA rearrangement is the common deletion (CD), characterized by the loss of nearly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07a4c8a8-374b-5ab1-9686-3cf1e0a1a4bb
DOI: 10.1101/2025.07.09.663484

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UVA irradiation promotes ROS-mediated formation of the common deletion in mitochondrial DNADOI 10.1101/2025.07.09.663484Read

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin CancerSemantic proximity Read

Detection of UV-Induced Deletions in Mitochondrial DNA.Semantic proximity Read

Role of Mitochondrial Dysfunction in UV ‐Induced Photoaging and Skin CancersSemantic proximity Read

The Interdependence of Skin Aging, Skin Cancer, and DNA Repair Capacity: A Novel Perspective with Therapeutic ImplicationsSemantic proximity Read

Mechanisms of UV-induced mutations and skin cancerSemantic proximity Read

How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissueSemantic proximity Read

Oxidative Stress and Genotoxicity in Melanoma Induction: Impact on Repair Rather Than Formation of DNA Damage?Semantic proximity Read

Impact of UV Radiation on Genome Stability and Human Health.Semantic proximity Read

Diversity of Biological Effects Induced by Longwave UVA Rays (UVA1) in Reconstructed SkinSemantic proximity Read

Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective StrategiesSemantic proximity Read

Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analysesSemantic proximity Read

The Use of a 3895 bp Mitochondrial DNA Deletion as a Marker for Sunlight Exposure in Human SkinSemantic proximity Read