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Article

A Case-Control Study of the Genetic Variability in Reactive Oxygen Species-Metabolizing Enzymes in Melanoma Risk.

International journal of molecular sciences - 14 Jan 2018

Yuan Tze-An, Yourk Vandy, Farhat Ali, Ziogas Argyrios, Meyskens Frank L, Anton-Culver Hoda, Liu-Smith Feng

Abstract excerpt

Recent studies have shown that ultraviolet (UV)-induced chemiexcitation of melanin fragments leads to DNA damage; and chemiexcitation of melanin fragments requires reactive oxygen species (ROS), as ROS excite an electron in the melanin fragments. In addition, ROS also cause DNA damages on their own. We hypothesized that ROS producing and metabolizing enzymes were major contributors in UV-driven melanomas. In this...

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Source

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Identifiers

PMID: 29342889
DOI: 10.3390/ijms19010242
PMCID: PMC5796190

Genes

RAC1
SOD2
SOD3
CYBA
CAT
NOX1
NOX4
SOD1

Provenance

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