Article
Mitochondrial DNA deletions in skin from melanoma patients.
Ethnicity & disease - 1 Jan 2008
Hubbard Karen, Steinberg Mark L, Hill Helene, Orlow Irene
Abstract excerpt
We measured the cellular levels of two types of mitochondrial DNA (mtDNA) deletions--the 4977-bp common deletion and recently identified UVB-induced deletion of 5128 bp--in apparently normal skin obtained from wide excisions in melanoma patients. The number of deleted mtDNAs as well as the total mtDNA copy number was highly variable, but the number of deletions increased with age of the donor almost 12-fold...
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