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Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli

29 Apr 2014

Abstract excerpt

Two-component systems (TCSs) are highly conserved across bacteria and are used to rapidly sense and respond to changing environmental conditions. The human pathogen Staphylococcus aureus uses the S. aureus exoprotein expression (sae) TCS to sense host signals and activate transcription of virulence factors essential to pathogenesis. Despite its importance, the mechanism by which the histidine kinase SaeS...

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PMID: 24782537
DOI: 10.1073/pnas.1322125111

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