Article

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of <i>Staphylococcus aureus</i>

2018-08-31

Abstract excerpt

<h4>ABSTRACT</h4> WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone appears not to explain its essentiality. To understand WalKR function we investigated a suppressor mutant that arose when WalKR activity was impaired; a single histidine to tryptophan substitution (H271Y) in the cytoplasmic Per...

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Literature Corpus work: c20ae20c-cc3e-5604-85ed-37ade223a92d
DOI: 10.1101/405365

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