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Article

RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary.

The Journal of pathology - 1 Feb 2013

Ryland Georgina L, Hunter Sally M, Doyle Maria A, Rowley Simone M, Christie Michael, Allan Prue E, Bowtell David D L, Gorringe Kylie L, Campbell Ian G

Abstract excerpt

Mucinous carcinomas represent a distinct morphological subtype which can arise from several organ sites, including the ovary, and their genetic characteristics are largely under-described. Exome sequencing of 12 primary mucinous ovarian tumours identified RNF43 as the most frequently somatically mutated novel gene, secondary to KRAS and mutated at a frequency equal to that of TP53 and BRAF. Further screening of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23096461
DOI: 10.1002/path.4134

Genes

RNF43
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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