Article
MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis.
Genes, chromosomes & cancer - 1 Jun 2015
Nelson David S, van Halteren Astrid, Quispel Willemijn T, van den Bos Cor, Bovée Judith V M G, Patel Bhumi, Badalian-Very Gayane, van Hummelen Paul, Ducar Matthew, Lin Ling, MacConaill Laura E, Egeler R Maarten, Rollins Barrett J
Abstract excerpt
Langerhans cell histiocytosis (LCH) is now understood to be a neoplastic disease in which over 50% of cases have somatic activating mutations of BRAF. However, the extracellular signal-related (ERK) pathway is activated in all cases including those with wild type BRAF alleles. Here, we applied a targeted massively parallel sequencing panel to 30 LCH samples to test for the presence of additional genetic...
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