Article
Dimerization of G-protein-coupled receptors.
Journal of medicinal chemistry - 20 Dec 2001
Dean M K, Higgs C, Smith R E, Bywater R P, Snell C R, Scott P D, Upton G J, Howe T J, Reynolds C A
Abstract excerpt
The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned G-protein-coupled receptor (GPCR) sequences. The method predicted the occurrence of functionally important clusters of residues on the external faces of helices 5 and 6 for each family or subfamily of receptors; similar clusters were observed on helices 2...
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