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Article

Deletion of endogenous Tau proteins is not detrimental in Drosophila

15 Mar 2016

Abstract excerpt

Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis of Alzheimer's disease (AD), constituting, together with accumulated β-amyloid (Aβ) peptides, a hallmark of the disease. Deciphering both the loss-of-function and toxic gain-of-function of hTau proteins...

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PMID: 26976084
DOI: 10.1038/srep23102

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