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Article

Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro.

The Journal of infectious diseases - 15 Jul 2003

Hanekom Willem A, Mendillo Megan, Manca Claudia, Haslett Patrick A J, Siddiqui M Ruby, Barry Clifton, Kaplan Gilla

Abstract excerpt

To induce effector immunity, dendritic cells (DCs) must differentiate into fully mature cells. We show that, after human monocyte-derived DCs were infected with virulent Mycobacterium tuberculosis, up-regulation of cellular-surface maturation markers was minimal and reversible. In the presence of a potent stimulus for maturation (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, and prostaglandin E2...

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Identifiers

PMID: 12854081
DOI: 10.1086/376451

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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