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Article

Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype.

Cytokine - 1 May 2015

Nakamura Kiwamu, Ito Ichiaki, Kobayashi Makiko, Herndon David N, Suzuki Fujio

Abstract excerpt

Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities. However, it is unknown which phenotypes of M2 macrophages are induced by ORM. In this study, healthy donor monocytes stimulated with ORM (ORM-monocytes) were characterized phenotypically and biologically. CCL1 (a biomarker of M2b...

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Source

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Identifiers

PMID: 25689617
DOI: 10.1016/j.cyto.2015.01.017
PMCID: PMC4541791

Genes

ORM1
CCL1
ORM2
CCL17
CXCL13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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