Article
IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Nature communications - 14 Mar 2016
Iannitti Rossana G, Napolioni Valerio, Oikonomou Vasilis, De Luca Antonella, Galosi Claudia, Pariano Marilena, Massi-Benedetti Cristina, Borghi Monica, Puccetti Matteo, Lucidi Vincenzina, Colombo Carla, Fiscarelli Ersilia, Lass-Flörl Cornelia, Majo Fabio, Cariani Lisa, Russo Maria, Porcaro Luigi, Ricciotti Gabriella, Ellemunter Helmut, Ratclif Luigi, De Benedictis Fernando Maria, Talesa Vincenzo Nicola, Dinarello Charles A, van de Veerdonk Frank L, Romani Luigina
Abstract excerpt
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses in mice and humans with cystic fibrosis (CF), a life-threatening disorder of the lungs and digestive system....
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