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Article

Inflammasome and IL-1β-Mediated Disorders

27 Apr 2010

Abstract excerpt

The NLRP3 inflammasome is an intracellular complex that regulates the release of proinflammatory cytokines such as interleukin-1beta in response to exogenous pathogens and endogenous danger signals. Evidence from studies involving human genetics, human ex vivo mononuclear cell responses, and in vivo and in vitro murine models confirms the importance of the inflammasome and interleukin-1beta in the pathogenesis of...

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PMID: 20425006
DOI: 10.1007/s11882-010-0109-z

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