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Article

Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.

American journal of respiratory cell and molecular biology - 1 Aug 2021

Graustein Andrew D, Berrington William R, Buckingham Kati J, Nguyen Felicia K, Joudeh Lara L, Rosenfeld Margaret, Bamshad Michael J, Gibson Ronald L, Hawn Thomas R, Emond Mary J

Abstract excerpt

Cystic fibrosis (CF) is characterized by chronic airway infection, inflammation, and tissue damage that lead to progressive respiratory failure. NLRP3 and NLRC4 are cytoplasmic pattern recognition receptors that activate the inflammasome, initiating a caspase-1-mediated response. We hypothesized that gain-of-function inflammasome responses are associated with worse outcomes in children with CF. We genotyped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

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Identifiers

PMID: 33848452
DOI: 10.1165/rcmb.2020-0257OC
PMCID: PMC8399576

Genes

NLRP3
NLRC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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