Article
Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease.
Cellular microbiology - 1 Feb 2009
Döring Gerd, Gulbins Erich
Abstract excerpt
Innate immunity is essential for prevention of infection in vertebrates and plants and dysfunction of single components of innate immunity may provoke severe disease. Here we describe how mutations in the cystic fibrosis transmembrane conductance regulator gene dysregulate a variety of components...
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