Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.

doi:10.1093/hmg/ddt619

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Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.

Human molecular genetics - 1 May 2014

Almeida Rodrigo, Ricaño-Ponce Isis, Kumar Vinod, Deelen Patrick, Szperl Agata, Trynka Gosia, Gutierrez-Achury Javier, Kanterakis Alexandros, Westra Harm-Jan, Franke Lude, Swertz Morris A, Platteel Mathieu, Bilbao Jose Ramon, Barisani Donatella, Greco Luigi, Mearin Luisa, Wolters Victorien M, Mulder Chris, Mazzilli Maria Cristina, Sood Ajit, Cukrowska Bozena, Núñez Concepción, Pratesi Riccardo, Withoff Sebo, Wijmenga Cisca

Abstract excerpt

Using the Immunochip for genotyping, we identified 39 non-human leukocyte antigen (non-HLA) loci associated to celiac disease (CeD), an immune-mediated disease with a worldwide frequency of ∼1%. The most significant non-HLA signal mapped to the intronic region of 70 kb in the LPP gene. Our aim was to fine map and identify possible functional variants in the LPP locus. We performed a meta-analysis in a cohort of...

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PMID: 24334606
DOI: 10.1093/hmg/ddt619
PMCID: PMC3976328

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