Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection.

doi:10.1161/ATVBAHA.115.307049

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Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Brinck Jonas W, Thomas Aurélien, Lauer Estelle, Jornayvaz François R, Brulhart-Meynet Marie-Claude, Prost Jean-Christophe, Pataky Zoltan, Löfgren Patrik, Hoffstedt Johan, Eriksson Mats, Pramfalk Camilla, Morel Sandrine, Kwak Brenda R, van Eck Miranda, James Richard W, Frias Miguel A

Abstract excerpt

OBJECTIVE: The dyslipidemia of type 2 diabetes mellitus has multiple etiologies and impairs lipoprotein functionality, thereby increasing risk for cardiovascular disease. High-density lipoproteins (HDLs) have several beneficial effects, notably protecting the heart from myocardial ischemia. We hypothesized that glycation of HDL could compromise this cardioprotective effect. APPROACH AND RESULTS: We used in vitro...

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PMID: 26966278
DOI: 10.1161/ATVBAHA.115.307049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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