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Article

S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.

American journal of physiology. Heart and circulatory physiology - 1 May 2011

Bandhuvula Padmavathi, Honbo Norman, Wang Guan-Ying, Jin Zhu-Qiu, Fyrst Henrik, Zhang Meng, Borowsky Alexander D, Dillard Lisa, Karliner Joel S, Saba Julie D

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning. S1P lyase (SPL) is a stress-activated enzyme responsible for irreversible S1P catabolism. We hypothesized that SPL contributes to oxidative stress by depleting S1P pools available for cardioprotective signaling. Accordingly, we evaluated SPL inhibition as a strategy for...

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Identifiers

PMID: 21335477
DOI: 10.1152/ajpheart.00946.2010
PMCID: PMC3094087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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