Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.

Cardiovascular drugs and therapy - 1 Dec 2019

Tate Mitchel, Higgins Gavin C, De Blasio Miles J, Lindblom Runa, Prakoso Darnel, Deo Minh, Kiriazis Helen, Park Min, Baeza-Garza Carlos D, Caldwell Stuart T, Hartley Richard C, Krieg Thomas, Murphy Michael P, Coughlan Melinda T, Ritchie Rebecca H

Abstract excerpt

PURPOSE: Methylglyoxal, a by-product of glycolysis and a precursor in the formation of advanced glycation end-products, is significantly elevated in the diabetic myocardium. Therefore, we sought to investigate the mitochondria-targeted methylglyoxal scavenger, MitoGamide, in an experimental model of spontaneous diabetic cardiomyopathy. METHODS: Male 6-week-old Akita or wild type mice received daily oral gavage of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amides
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiotonic Agents

Share to Insulin

Share to Mice, Inbred C57BL

Share to Mitochondria, Heart

Share to Pyruvaldehyde

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 31654171
DOI: 10.1007/s10557-019-06914-9
PMCID: PMC6994445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.PMID 31654171Read ↗

Methylglyoxal in Cardiometabolic Disorders – Routes Leading to Pathology – Counterbalanced by Treatment StrategiesSemantic proximity Read ↗

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment OptionsSemantic proximity Read ↗

Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy: molecular snapshot of a severe myocardial diseaseSemantic proximity Read ↗

Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction.Semantic proximity Read ↗

Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heartSemantic proximity Read ↗

Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice.Semantic proximity Read ↗

Molecular Assessment of Methylglyoxal-Induced Toxicity and Therapeutic Approaches in Various Diseases: Exploring the Interplay with the Glyoxalase SystemSemantic proximity Read ↗

Endogenous adenine is a potential driver of the cardiovascular-kidney-metabolic syndromeSemantic proximity Read ↗

Of cells and tissues: Identifying the elements of a diabetic cardiac in vitro study modelSemantic proximity Read ↗

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.Semantic proximity Read ↗

Trimethylamine N-oxide impairs β-cell function and glucose toleranceSemantic proximity Read ↗

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.