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Article

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

Circulation research - 25 Sept 2015

Chen Hsiao-Huei, Keyhanian Kianoosh, Zhou Xun, Vilmundarson Ragnar O, Almontashiri Naif A M, Cruz Shelly A, Pandey Nihar R, Lerma Yap Nida, Ho Tiffany, Stewart Chloe A, Huang Hua, Hari Aswin, Geoffrion Michele, McPherson Ruth, Rayner Katey J, Stewart Alexandre F R

Abstract excerpt

RATIONALE: Inflammation impairs macrophage cholesterol clearance from vascular tissues and promotes atherosclerosis. Inflammatory macrophages suppress expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP2), and genetic variants near IRF2BP2 associate with ischemic heart disease progression in humans. OBJECTIVES: To test whether IRF2BP2 in macrophages affects...

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Identifiers

PMID: 26195219
DOI: 10.1161/CIRCRESAHA.114.305777

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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