Article
The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis.
Cardiovascular research - 1 Jun 2018
van der Heijden Charlotte D C C, Deinum Jaap, Joosten Leo A B, Netea Mihai G, Riksen Niels P
Abstract excerpt
The mineralocorticoid receptor (MR) is a member of the nuclear receptor steroid-binding family. The classical MR ligand aldosterone controls electrolyte and fluid homeostasis after binding in renal epithelial cells. However, more recent evidence suggests that activation of extrarenal MRs by aldosterone negatively impacts cardiovascular health independent of its effects on blood pressure: high levels of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.