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Article

Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.

Molecular cancer research : MCR - 1 May 2016

Frum Rebecca A, Love Ian M, Damle Priyadarshan K, Mukhopadhyay Nitai D, Palit Deb Swati, Deb Sumitra, Grossman Steven R

Abstract excerpt

UNLABELLED: Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared with wild-type p53 in tumors, contributing to mutant p53's gain-of-function oncogenic properties. Here, a novel mechanism is revealed for the maintenance of mutant p53 abundance in cancer that is dependent on DNA damage checkpoint activation. High-level mutant p53 expression in lung cancer cells was...

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Identifiers

PMID: 26965143
DOI: 10.1158/1541-7786.MCR-15-0363
PMCID: PMC5110038

Genes

ATM
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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