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Article

Polymorphisms of Dectin-1 and TLR2 Predispose to Invasive Fungal Disease in Patients with Acute Myeloid Leukemia.

PloS one - 1 Jan 2016

Fischer Mike, Spies-Weisshart Baerbel, Schrenk Karin, Gruhn Bernd, Wittig Susan, Glaser Anita, Hochhaus Andreas, Scholl Sebastian, Schnetzke Ulf

Abstract excerpt

BACKGROUND: Patients with acute myeloid leukemia (AML) who undergo induction chemotherapy are at high risk for invasive fungal disease (IFD). Dectin-1, a C-type lectin family member represents one of the most important pattern recognition receptors of the innate immune system and single nucleotide polymorphisms (SNPs) in the Dectin-1 gene have been associated with an increased risk of infectious complications. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Lectins, C-Type

Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 26963509
DOI: 10.1371/journal.pone.0150632
PMCID: PMC4786091

Genes

TLR2

Variants

rs5743708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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