Article
Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease.
Blood advances - 12 Jan 2021
Vedula Rahul S, Cheng Matthew P, Ronayne Christine E, Farmakiotis Dimitrios, Ho Vincent T, Koo Sophia, Marty Francisco M, Lindsley R Coleman, Bold Tyler D
Abstract excerpt
Invasive fungal disease (IFD) can be a severe treatment complication in patients with myeloid malignancies, but current risk models do not incorporate disease-specific factors, such as somatic gene mutations. Germline GATA2 deficiency is associated with a susceptibility to IFD. To determine whether myeloid gene mutations were associated with IFD risk, we identified 2 complementary cohorts of patients with myeloid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.