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Validating genetic variants in innate immunity linked to infectious events in acute myeloid leukemia post-induction chemotherapy.

Genes and immunity - 1 Aug 2024

Schnetzke Ulf, Fischer Mike, Röllig Christoph, Scherag André, Altmann Heidi, Stölzel Friedrich, Alakel Nael, Bornhäuser Martin, Hochhaus Andreas, Scholl Sebastian

Abstract excerpt

Infectious events, such as sepsis and invasive fungal disease (IFD), pose significant risks in patients with acute myeloid leukemia (AML). Previous studies, including our own, have suggested a potential role of single nucleotide polymorphisms (SNPs) within the innate immune system in influencing individual infection susceptibility. However, many of these associations lack validation in independent cohorts. This...

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C-Reactive Protein
Cell Adhesion Molecules
Induction Chemotherapy
Lectins, C-Type
Sepsis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serum Amyloid P-Component

Toll-Like Receptor 2

Toll-Like Receptor 4

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Open in PubMed Open full text

Identifiers

PMID: 38982248
DOI: 10.1038/s41435-024-00285-4
PMCID: PMC11327101

Genes

PTX3
TLR2
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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