Article
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study.
Scientific reports - 12 Jul 2018
Chang Tien-Jyun, Wang Wen-Chang, Hsiung Chao A, He Chih-Tsueng, Lin Ming-Wei, Sheu Wayne Huey-Herng, Chang Yi-Cheng, Quertermous Tom, Chen Yii-Der Ida, Rotter Jerome I, Chuang Lee-Ming
Abstract excerpt
The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine...
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