Article
Genome-wide association study of blood pressure and hypertension.
Nature genetics - 1 Jun 2009
Levy Daniel, Ehret Georg B, Rice Kenneth, Verwoert Germaine C, Launer Lenore J, Dehghan Abbas, Glazer Nicole L, Morrison Alanna C, Johnson Andrew D, Aspelund Thor, Aulchenko Yurii, Lumley Thomas, Köttgen Anna, Vasan Ramachandran S, Rivadeneira Fernando, Eiriksdottir Gudny, Guo Xiuqing, Arking Dan E, Mitchell Gary F, Mattace-Raso Francesco U S, Smith Albert V, Taylor Kent, Scharpf Robert B, Hwang Shih-Jen, Sijbrands Eric J G, Bis Joshua, Harris Tamara B, Ganesh Santhi K, O'Donnell Christopher J, Hofman Albert, Rotter Jerome I, Coresh Josef, Benjamin Emelia J, Uitterlinden André G, Heiss Gerardo, Fox Caroline S, Witteman Jacqueline C M, Boerwinkle Eric, Wang Thomas J, Gudnason Vilmundur, Larson Martin G, Chakravarti Aravinda, Psaty Bruce M, van Duijn Cornelia M
Abstract excerpt
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P <...
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