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Article

Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients.

Clinical biochemistry - 1 Jul 2016

Bayoglu Burcu, Yuksel Husniye, Cakmak Huseyin Altug, Dirican Ahmet, Cengiz Mujgan

Abstract excerpt

OBJECTIVES: Hypertension (HT) is a complex disorder influenced by both genetic and environmental factors. Recent genome-wide association studies have identified a major risk locus for atherosclerosis on chromosome 9p21.3. SNPs within the coding sequences of CDKN2A/B and the long non-coding RNA CDKN2B-AS1 could potentially contribute to HT development. Thus, this study aimed to investigate whether the frequency of...

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PMID: 26944720
DOI: 10.1016/j.clinbiochem.2016.02.012

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