Article
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.
Human molecular genetics - 15 May 2016
Verweij Niek, Mateo Leach Irene, Isaacs Aaron, Arking Dan E, Bis Joshua C, Pers Tune H, Van Den Berg Marten E, Lyytikäinen Leo-Pekka, Barnett Phil, Wang Xinchen, Soliman Elsayed Z, Van Duijn Cornelia M, Kähönen Mika, Van Veldhuisen Dirk J, Kors Jan A, Raitakari Olli T, Silva Claudia T, Lehtimäki Terho, Hillege Hans L, Hirschhorn Joel N, Boyer Laurie A, Van Gilst Wiek H, Alonso Alvaro, Sotoodehnia Nona, Eijgelsheim Mark, De Boer Rudolf A, De Bakker Paul I W, Franke Lude, Van Der Harst Pim
Abstract excerpt
The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype-phenotype associations...
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