Article
Evaluation of 2 real-time PCR assays for in vitro diagnostic use in the rapid and multiplex detection of EGFR gene mutations in NSCLC.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2013
Wong Anthony T C, To Rene M Y, Wong Chris L P, Chan Wai-Kong, Ma Edmond S K
Abstract excerpt
Activating mutations of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer predict for a favorable clinical response to tyrosine kinase inhibitor therapy. Although Sanger sequencing is a conventional method to detect EGFR gene mutations, multiplex real-time allele-specific polymerase chain reaction (PCR) systems are increasingly used in the routine molecular diagnostic setting. We aim...
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