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Article

The association of EGFR amplification with aberrant exon 20 insertion report using the cobas EGFR Mutation Test v2.

PloS one - 1 Jan 2024

Zhang Man-San, Yeh Yi-Chen, Huang Hsien-Neng, Lin Long-Wei, Huang Yen-Lin, Wang Lei-Chi, Yao Lai-Jin, Hung Tze-Chun, Tseng Yu-Fen, Lee Yi-Hsuan, Liao Wei-Yu, Shih Jin-Yuan, Hsieh Min-Shu

Abstract excerpt

Determining the exact type of epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutation in lung cancer has become important. We found that not all ex20ins mutations reported by cobas EGFR test v2 could be validated by Sanger sequencing even using surgical specimens with high tumor contents. This study aimed to validate the ex20ins results reported by the cobas test and to determine whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38687753
DOI: 10.1371/journal.pone.0301120
PMCID: PMC11060574

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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