Article
Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.
BMC cancer - 27 Apr 2013
O'Donnell Patrick, Ferguson Jane, Shyu Johnny, Current Robert, Rehage Taraneh, Tsai Julie, Christensen Mari, Tran Ha Bich, Chien Sean Shih-Chang, Shieh Felice, Wei Wen, Lawrence H Jeffrey, Wu Lin, Schilling Robert, Bloom Kenneth, Maltzman Warren, Anderson Steven, Soviero Stephen
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutations identify patients with non-small cell lung cancer (NSCLC) who have a high likelihood of benefiting from treatment with anti-EGFR tyrosine kinase inhibitors. Sanger sequencing is widely used for mutation detection but can be technically challenging, resulting in longer turn-around-time, with limited sensitivity for low levels of mutations. This...
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