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Article

Identification of Actionable Gene Variants in Pulmonary Large-Cell Neuroendocrine Carcinoma: A Real-World Analysis of a Polish Cohort.

International journal of molecular sciences - 24 Mar 2026

Szpechcinski Adam, Pelc Magdalena, Lechowicz Urszula, Szolkowska Malgorzata, Moes-Sosnowska Joanna, Rudzinski Piotr, Wojda Emil, Skronska Paulina, Podgorska Elzbieta, Maszkowska-Kopij Krystyna, Polaczek Mateusz, Orlowski Tadeusz, Langfort Renata, Chorostowska-Wynimko Joanna

Abstract excerpt

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare lung malignancy characterized by an aggressive clinical course and an unfavorable prognosis. Next-generation sequencing (NGS) has revealed that LCNECs exhibit molecular features resembling either small-cell lung carcinoma (SCLC-like LCNEC) or non-small cell lung carcinoma (NSCLC-like LCNEC). This study aimed to characterize the incidence of...

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Identifiers

PMID: 41977128
DOI: 10.3390/ijms27072939
PMCID: PMC13073004

Genes

BRAF
EGFR
KRAS
NTRK1
PIK3CA
RET
ALK
FGFR1
ROS1
TMEM79

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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Identification of Actionable Gene Variants in Pulmonary Large-Cell Neuroendocrine Carcinoma: A Real-World Analysis of a Polish Cohort.PMID 41977128Read ↗

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