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Article

Divergent biology and outcomes of somatic transformations in germ cell tumors.

The oncologist - 8 Jul 2026

Thomas Zachariah, Johns Andrew C, Glover Michael, Crupi Emanuele, Nieto Yago L, Ward John F, Karam Jose A, Hofstetter Wayne L, Desai Monica, Choi Seungtaek L, Shah Amishi Y, Lin John, Moussa Mohammad Jad, Jiang Cindy Y, Alhalabi Omar, Campbell Matthew T

Abstract excerpt

PURPOSE: Somatic-type malignancy (SM) of germ cell tumor (GCT) is rare but demonstrates aggressive behavior. Differences by primary site, time to transformation, and mutational status remain poorly characterized. PATIENTS AND METHODS: We reviewed all SM patients between June 2016 and May 2025 at a tertiary referral center. Time to somatic transformation (TST) was defined from the initial GCT diagnosis to SM...

Topics

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Cell Transformation, Neoplastic
TP53 gene
TST gene
Mediastinal Neoplasms
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Germ Cell and Embryonal

Testicular Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 42378441
DOI: 10.1093/oncolo/oyag253
PMCID: PMC13364673

Genes

PTEN
TP53
TST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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