Article
Genomic characteristics revealed by targeted exon sequencing of testicular germ cell tumors in Japanese men.
International journal of urology : official journal of the Japanese Urological Association - 1 Jan 2021
Matsumoto Takashi, Shiota Masaki, Uchiumi Takeshi, Ueda Shohei, Tsukahara Shigehiro, Toshima Takahiro, Matsumoto Shinya, Noda Nozomi, Eto Masatoshi, Kang Dongchon
Abstract excerpt
OBJECTIVE: To investigate the somatic mutation profiles of testicular germ cell tumors in Japanese men. METHODS: We analyzed the somatic missense mutation profile of testicular germ cell tumors among 21 Japanese men with seminoma (n = 14), pure embryonic carcinoma (n = 3) and mixed testicular germ cell tumor (n = 4) by targeted next-generation sequencing of 409 cancer-related genes covering 1.23 Mb of the genome....
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