Article
RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors.
Urology - 1 Oct 2020
Mata Douglas A, Yang Soo-Ryum, Ferguson Donna C, Liu Ying, Sharma Rohit, Benhamida Jamal K, Al-Ahmadie Hikmat A, Chakravarty Debyani, Solit David B, Tickoo Satish K, Gupta Sounak, Arcila Maria E, Ladanyi Marc, Feldman Darren R, Reuter Victor E, Vanderbilt Chad M
Abstract excerpt
OBJECTIVE: To report the mutational profile and clinical outcomes of a cohort of patients with KIT-mutant seminomas and nonseminomatous germ-cell tumors (SGCT/NSGCTs). PATIENTS AND METHODS: Retrospective cohort study of all patients with KIT-mutant GCTs sequenced at Memorial Sloan Kettering between March 2014 and March 2020. Tumors were assessed with MSK-IMPACT, a DNA next-generation sequencing assay for targeted...
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