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Article

Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice.

PloS one - 1 Jan 2016

Godin Lindsay M, Sandri Brian J, Wagner Darcy E, Meyer Carolyn M, Price Andrew P, Akinnola Ifeolu, Weiss Daniel J, Panoskaltsis-Mortari Angela

Abstract excerpt

The lung changes functionally and structurally with aging. However, age-related effects on the extracellular matrix (ECM) and corresponding effects on lung cell behavior are not well understood. We hypothesized that ECM from aged animals would induce aging-related phenotypic changes in healthy inoculated cells. Decellularized whole organ scaffolds provide a powerful model for examining how ECM cues affect cell...

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Identifiers

PMID: 26954258
DOI: 10.1371/journal.pone.0150966
PMCID: PMC4783067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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