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Article

Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018

Wagner Julian U G, Chavakis Emmanouil, Rogg Eva-Maria, Muhly-Reinholz Marion, Glaser Simone F, Günther Stefan, John David, Bonini Francesca, Zeiher Andreas M, Schaefer Liliana, Hannocks Melanie-Jane, Boon Reinier A, Dimmeler Stefanie

Abstract excerpt

OBJECTIVE: Endothelial cells play important roles in tissue homeostasis and vascularization, a function that is impaired by aging. Here, we aim to decipher the role of the microenvironment underlying the impairment of endothelial cell functions by aging. APPROACH AND RESULTS: RNA sequencing of isolated cardiac endothelial cells derived from young and 18-month-old mouse hearts revealed that aging affects the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29599141
DOI: 10.1161/ATVBAHA.117.310685

Genes

ITGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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