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Article

Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2021

Bahcecioglu Gokhan, Yue Xiaoshan, Howe Erin, Guldner Ian, Stack M Sharon, Nakshatri Harikrishna, Zhang Siyuan, Zorlutuna Pinar

Abstract excerpt

Age is a major risk factor for cancer. While the importance of age related genetic alterations in cells on cancer progression is well documented, the effect of aging extracellular matrix (ECM) has been overlooked. This study shows that the aging breast ECM alone is sufficient to drive normal human mammary epithelial cells (KTB21) to a more invasive and cancer-like phenotype, while promoting motility and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34617419
DOI: 10.1002/advs.202100128
PMCID: PMC8596116

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