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Article

Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2023

Gonzalez Nicole, Rao Nina, Dean Michael, Lee Donghyuk, Hurson Amber N, Baris Dalsu, Schwenn Molly, Johnson Alison, Prokunina-Olsson Ludmila, Friesen Melissa C, Zhu Bin, Rothman Nathaniel, Silverman Debra T, Koutros Stella

Abstract excerpt

BACKGROUND: Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors. METHODS: Targeted...

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Identifiers

PMID: 36996403
DOI: 10.1158/1055-9965.EPI-22-1208
PMCID: PMC10239365

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