Article
Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors.
Environmental health perspectives - 1 Apr 2010
Mordukhovich Irina, Rossner Pavel, Terry Mary Beth, Santella Regina, Zhang Yu-Jing, Hibshoosh Hanina, Memeo Lorenzo, Mansukhani Mahesh, Long Chang-Min, Garbowski Gail, Agrawal Meenakshi, Gaudet Mia M, Steck Susan E, Sagiv Sharon K, Eng Sybil M, Teitelbaum Susan L, Neugut Alfred I, Conway-Dorsey Kathleen, Gammon Marilie D
Abstract excerpt
BACKGROUND: Previous studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. However, the carcinogenicity of PAHs on the human breast remains unclear. Certain carcinogens may be associated with specific mutation patterns in the p53 tumor suppressor gene, thereby contributing information about disease etiology. OBJECTIVES: We hypothesized that associations of...
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